Acute liver failure future or investigational therapies
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Liver support systems can help support patients until the liver recovers or can be used as a bridging aid in transplant patients.
Future or Investigational Therapies
Liver Support Systems
Liver Support Systems are support devices that compensate for a failing liver. These devices can also be used as a bridging aid in transplant patients. There are two kinds of devices: sorbent-based artificial systems and cell-based bio-artificial systems. There is no good evidence showing low mortality with the use of either system in acute liver failure.
These are sorbent-based systems that assist in detoxification. They may use charcoal or other sorbents like albumin. Such systems operate on the principles of plasmapheresis. They are most useful in reducing effects in hepatic encephalopathy due to their efficacy in detoxification.
These are cell-based systems. These systems use cells (hepatocytes of human or mammalian origin) in a cartridge or circuit fashion. There is published data on five systems. No system has yet to show any survival advantage. 
Other strategies include exchange transfusion, charcoal hemoperfusion, extracorporeal liver perfusions, and intra-portal hepatocyte infusions. All these are still being evaluated in trials and no evidence of good prognosis has been demonstrated.
2011 AASLD Recommendations for Acute Liver Failure (DO NOT EDIT)
Liver Support Systems (DO NOT EDIT)
|1. Currently available liver support systems are not recommended outside of clinical trials; their future in the management of acute liver failure remains unclear.
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