Acinic cell carcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

Based on the 8th edition of American Joint Committee on Cancer(AJCC) and Union for International Cancer Control (UICC)the staging of salivary gland neoplasms are staged by TNM system.This means acinic cell carcinoma is staged based on tumor, node, and metastasis similar to squamous cell carcinoma.

Classification

Based on the 8th edition of American Joint Committee on Cancer(AJCC) and Union for International Cancer Control (UICC) the staging of salivary gland neoplasms are staged by TNM system. This means acinic cell carcinoma is staged based on tumor, node, and metastasis similar to squamous cell carcinoma.[1]

T: Primary Tumor

T Description
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Ta Papillary noninvasive carcinoma
Tis Carcinoma in situ
T1 Tumor invades subepithelial connective tissue
T2 Tumor invades the muscularis
T3 (For renal pelvis only) Tumor invades beyond muscularis into peripelvic fat or the renal parenchyma T3. (For ureter only) Tumor invades beyond muscularis into periureteric fat
T4 Tumor invades adjacent organs, or through the kidney into the perinephric fat

N:Regional Lymph Nodes

N Description
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis in a single lymph node, ≤2 cm in greatest dimension
N2 Metastasis in a single lymph node, >2 cm but not >5 cm in greatest dimension; or multiple lymph nodes, none >5 cm in greatest dimension
N3 Metastasis in a lymph node, >5 cm in greatest dimension


M: Distant Metastasis

T Description
M0 There is no evidence of distant metastasis
M1 There is evidence of distant metastasis

TNM Classification

Stage T N M
Stage 0a Ta N0 M0
Stage 0is Tis N0 M0
Stage I T1 N0 M0
Stage II T2 N0 M0
Stage III T3 N0 M0
Stage IV T4 N0 M0
Any T N1 M0
Any T N2 M0
Any T N3 M0
Any T Any N M1

* Acinic cell carcinoma is classified due its different histiological featurs as bellow:[2]


Acinic-intercalated ductal carcinoma family
Solid acinic cell carcinoma Serous cells adenocarsinoma
Cacinomas of various proportions Various proportion of acinic and intercalated duct-like cells
Carcinomas intercalated duct-like cells Microcytic, papillary, follicular, cystic and mixed architectural arrangments
s-100 protein (-) Considered immunohistochemisty for DOGI
s-100 protein (+)/MASC Consider immunohistochemistry for mammaglobin, ETV6 FISH


References

  1. Son, Eugene; Panwar, Aru; Mosher, Charles H.; Lydiatt, Daniel (2018). "Cancers of the Major Salivary Gland". Journal of Oncology Practice. 14 (2): 99–108. doi:10.1200/JOP.2017.026856. ISSN 1554-7477.
  2. Chiosea, Simion I.; Griffith, Christopher; Assaad, Adel; Seethala, Raja R. (2012). "The Profile of Acinic Cell Carcinoma After Recognition of Mammary Analog Secretory Carcinoma". The American Journal of Surgical Pathology. 36 (3): 343–350. doi:10.1097/PAS.0b013e318242a5b0. ISSN 0147-5185.

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