Acid phosphatase

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Acid phosphatase

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Acid phosphatase is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion.It is basically a phospho homo esterase . It is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum.

Different forms of acid phosphatase are found in different organs, and their serum levels are used as a diagnostic for disease in the corresponding organs. For example, elevated prostatic acid phosphatase levels may indicate the presence of prostate cancer.

Acid phosphatase catalyzes the following reaction at an optimal pH below 7:

Orthophosphoric monoester + H2O → alcohol + H3PO4

Differential Diagnosis

Common causes of Increased Acid Phosphatase

[1] [2]


Causes by Organ System

Cardiovascular Rheumatic fever
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Mirtazapine , Leuprolide , Histrelin , Leuprolide , Amifostine , Buserelin
Ear Nose Throat Cholesteatoma , Mastoiditis in adults , Chronic otitis media
Endocrine Hyperparathyroidism
Environmental No underlying causes
Gastroenterologic Diseases of the liver , Primary biliary cirrhosis , Jaundice , Hepatotoxicity , Alcoholic Hepatitis
Genetic No underlying causes
Hematologic Sickle cell disease , Murine Leukemia , Multiple myeloma , Hemolysed blood sample , Haemolytic anaemia , Disseminated intravascular coagulation , Diseases of spleen
Iatrogenic No underlying causes
Infectious Disease Rheumatic fever , Chronic otitis media, , Mastoiditis in adults , Cholesteatoma
Musculoskeletal / Ortho Paget disease of bone , Osteopetrosis
Neurologic No underlying causes
Nutritional / Metabolic Glycogen storage disease , Gaucher disease
Obstetric/Gynecologic No underlying causes
Oncologic Prostate cancer , Extrapulmonary small cell cancer , Prostate cancer , Murine Leukemia , Multiple myeloma , Hairy cell leukemia , Bone metastases,
Ophthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Glucocorticoid-resistant asthma , Extrapulmonary small cell cancer , Diseases of lungs
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Systemic lupus erythematosus , Myopathy , Rheumatic fever
Sexual No underlying causes
Trauma No underlying causes
Urologic Prostatitis , Prostate cancer , Castration resistant prostate cancer , Prostate instrumentation
Dental No underlying causes
Miscellaneous Diseases of spleen

Causes in Alphabetical Order

See also

External links



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  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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