Acetylmethadol

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Acetylmethadol
File:Acetylmethadol.svg
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  • None
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E number{{#property:P628}}
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Chemical and physical data
FormulaC23H31NO2
Molar mass353.498 g/mol
3D model (JSmol)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Acetylmethadol (INN), also known as methadyl acetate (USAN), is a synthetic opioid analgesic.[1] It is a racemic mixture of alphacetylmethadol (α-acetylmethadol) and betacetylmethadol (β-acetylmethadol), which are in turn racemic mixtures of levacetylmethadol (LAAM; L-α-acetylmethadol) and D-α-acetylmethadol and L-β-acetylmethadol and D-β-acetylmethadol, respectively.[1] Hence, acetylmethadol has four possible optical isomers.[1] All of these isomers have been shown to partially or fully substitute for the discriminative stimulus effects of heroin in rats, and thus it can be inferred that, in addition to LAAM which is used clinically as such, they are all likely to be active opioid analgesics in humans.[1]

In the United States, acetylmethadol and its individual isomers are all Schedule I drugs under the Controlled Substances Act.[2]

See also

References

  1. 1.0 1.1 1.2 1.3 Newman JL, Vann RE, May EL, Beardsley PM (2002). "Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats". Psychopharmacology. 164 (1): 108–14. doi:10.1007/s00213-002-1198-8. PMID 12373424. Unknown parameter |month= ignored (help)
  2. 21 U.S.C. § 812(b)(1)

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