Acetylenedicarboxylate decarboxylase

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In enzymology, an acetylenedicarboxylate decarboxylase (EC is an enzyme that catalyzes the chemical reaction

acetylenedicarboxylate + H2O pyruvate + CO2

Thus, the two substrates of this enzyme are acetylenedicarboxylate and H2O, whereas its two products are pyruvate and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is acetylenedicarboxylate carboxy-lyase (pyruvate-forming). Other names in common use include acetylenedicarboxylate hydratase, acetylenedicarboxylate hydrase, and acetylenedicarboxylate carboxy-lyase. This enzyme participates in pyruvate metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Yamada EW and Jakoby WB (1958). "Enzymatic utilization of acetylenic compounds. I. An enzyme converting acetylenedicarboxylic acid to pyruvate". J. Biol. Chem. 233: 706&ndash, 711.

External links

The CAS registry number for this enzyme class is 72561-10-5.

Gene Ontology (GO) codes