Acetyl-CoA C-acyltransferase

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acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)
Identifiers
SymbolACAA1
Entrez30
HUGO82
OMIM604054
RefSeqNM_001607
UniProtP09110
Other data
EC number2.3.1.16
LocusChr. 3 p23-p22
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
Identifiers
SymbolACAA2
Entrez10449
HUGO83
OMIM604770
RefSeqNM_006111
UniProtP42765
Other data
EC number2.3.1.16
LocusChr. 18 [1]

The final step of beta oxidation is the cleavage of 3-ketoacyl CoA by the thiol group of another molecule of CoA. This reaction is catalyzed by Acetyl-CoA C-acyltransferase (or Β-ketothiolase). The thiol is inserted between C-2 and C-3, which yields an acetyl CoA molecule and an acyl CoA molecule, which is two carbons shorter.

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