Acetone carboxylase

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In enzymology, an acetone carboxylase (EC is an enzyme that catalyzes the chemical reaction

acetone + CO2 + ATP + 2 H2O acetoacetate + AMP + 2 phosphate

The 4 substrates of this enzyme are acetone, CO2, ATP, and H2O, whereas its 3 products are acetoacetate, AMP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is acetone:carbon-dioxide ligase (AMP-forming).


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Sluis MK, Ensign SA (1997). "Purification and characterization of acetone carboxylase from Xanthobacter strain Py2". Proc. Natl. Acad. Sci. U. S. A. 94: 8456&ndash, 61. PMID 9237998.

External links

Gene Ontology (GO) codes