ATP-sensitive K+ channels

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potassium inwardly-rectifying channel, subfamily J, member 11
Identifiers
Symbol KCNJ11
Entrez 3767
HUGO 6257
OMIM 600937
RefSeq NM_000525
UniProt Q14654
Other data
Locus Chr. 11 p15.1

ATP-sensitive K+ channels is a type of potassium channel containing Kir6.2 and sulfonylurea receptors, along with additional subunits.[1]

It is usually closed in the heart; but when levels of ATP are reduced (as during ischemia), the channel opens. In the pancreatic islet beta cells the channel is usually open, but when ATP levels rise in response to the metabolism of high levels of glucose or amino acid metabolism the channel closes. This depolarizes the cell membrane, opens calcium ion channels and ultimately leads to an increase in insulin secretion. Defects in this pathway can lead to type 2 diabetes or hyperinsulinemia.

See also

References

  1. Stephan D, Winkler M, Kühner P, Russ U, Quast U (2006). "Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels.". Diabetologia. 49 (9): 2039–48. PMID 16865362. 

External links

  • "Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.". Pflugers Arch. PMID 17021801. 
  • MeSH KCNJ11+protein,+human



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