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RefSeq (mRNA)



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A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.[1][2][3]


The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.[3]


AKAP3 has been shown to interact with:


  1. Lefevre A, Duquenne C, Rousseau-Merck MF, Rogier E, Finaz C (May 1999). "Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition". Biochemical and Biophysical Research Communications. 259 (1): 60–6. doi:10.1006/bbrc.1999.0728. PMID 10334916.
  2. 2.0 2.1 Vijayaraghavan S, Liberty GA, Mohan J, Winfrey VP, Olson GE, Carr DW (May 1999). "Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein". Molecular Endocrinology. 13 (5): 705–17. doi:10.1210/mend.13.5.0278. PMID 10319321.
  3. 3.0 3.1 "Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3".
  4. Brown PR, Miki K, Harper DB, Eddy EM (Jun 2003). "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum". Biology of Reproduction. 68 (6): 2241–8. doi:10.1095/biolreprod.102.013466. PMID 12606363.
  5. Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA (Oct 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Current Biology. 11 (21): 1686–90. doi:10.1016/S0960-9822(01)00530-9. PMID 11696326.
  6. Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S (May 2001). "Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA". The Journal of Biological Chemistry. 276 (20): 17332–8. doi:10.1074/jbc.M011252200. PMID 11278869.

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Further reading