5.8S ribosomal RNA

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5.8S ribosomal RNA (5.8S rRNA) is a component of the large subunit of the eukaryotic ribosome. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Functionally, it is thought that 5.8S rRNA may be involved in ribosome translocation.[1] It is also known to form covalent linkage to the p53 tumour suppressor protein.[2] 5.8S rRNA is also found in archaea.


  1. Abou, Elela S (1997). "Role of the 5.8S rRNA in ribosome translocation". Nucleic Acids Res. 25: 1788&ndash, 1794. PMID 9108162. Unknown parameter |coauthors= ignored (help)
  2. Fontoura, BM (1997). "Cytoplasmic p53 polypeptide is associated with ribosomes". Mol Cell Biol. 17: 3146&ndash, 3154. PMID 9154813. Unknown parameter |coauthors= ignored (help)

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