4-hydroxybenzoyl-CoA thioesterase

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In enzymology, a 4-hydroxybenzoyl-CoA thioesterase (EC is an enzyme that catalyzes the chemical reaction

4-hydroxybenzoyl-CoA + H2O 4-hydroxybenzoate + CoA

Thus, the two substrates of this enzyme are 4-hydroxybenzoyl-CoA and H2O, whereas its two products are 4-hydroxybenzoate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 4-hydroxybenzoyl-CoA hydrolase. This enzyme participates in 2,4-dichlorobenzoate degradation.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1HN1, 1LO7, 1LO8, 1LO9, 1Q4S, 1Q4T, and 1Q4U.


  • IUBMB entry for
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  • Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D (1992). "Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3". Biochemistry. 31: 5605&ndash, 10. PMID 1610806.
  • Dunaway-Mariano D, Babbitt PC (1994). "On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway". Biodegradation. 5: 259&ndash, 76. PMID 7765837.

External links

The CAS registry number for this enzyme class is 141583-19-9.

Gene Ontology (GO) codes