- 4-hydroxy-4-methyl-2-oxoglutarate 2 pyruvate
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming). Other names in common use include pyruvate aldolase, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, 4-hydroxy-4-methyl-2-ketoglutarate aldolase, and 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. This enzyme participates in benzoate degradation via hydroxylation and c5-branched dibasic acid metabolism.
- IUBMB entry for 188.8.131.52
- BRENDA references for 184.108.40.206 (Recommended.)
- PubMed references for 220.127.116.11
- PubMed Central references for 18.104.22.168
- Google Scholar references for 22.214.171.124
- Maruyama K (Tokyo). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". J. Biochem.: 557&ndash, 65. PMID 6841353. Check date values in:
- Sharma ML, Kaul SM and Shukla OP (1984). "Metabolism of 2-hydroxypyridine by Bacillus brevis (INA)". Biol. Membr. 9: 43&ndash, 52.
- Tack BF, Chapman PJ, Dagley S (1972). "Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase". J. Biol. Chem. 247: 6444&ndash, 9. PMID 5076765.
- Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.
- The CAS registry number for this enzyme class is 37290-65-6.
Gene Ontology (GO) codes
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