4-hydroxy-4-methyl-2-oxoglutarate aldolase

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In enzymology, a 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC is an enzyme that catalyzes the chemical reaction

4-hydroxy-4-methyl-2-oxoglutarate 2 pyruvate

Hence, this enzyme has one substrate, 4-hydroxy-4-methyl-2-oxoglutarate, and one product, pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming). Other names in common use include pyruvate aldolase, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, 4-hydroxy-4-methyl-2-ketoglutarate aldolase, and 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. This enzyme participates in benzoate degradation via hydroxylation and c5-branched dibasic acid metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Maruyama K (Tokyo). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". J. Biochem.: 557&ndash, 65. PMID 6841353. Check date values in: |date= (help)
  • Sharma ML, Kaul SM and Shukla OP (1984). "Metabolism of 2-hydroxypyridine by Bacillus brevis (INA)". Biol. Membr. 9: 43&ndash, 52.
  • Tack BF, Chapman PJ, Dagley S (1972). "Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase". J. Biol. Chem. 247: 6444&ndash, 9. PMID 5076765.
  • Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.

External links

The CAS registry number for this enzyme class is 37290-65-6.

Gene Ontology (GO) codes