3-ethylmalate synthase

Jump to: navigation, search

In enzymology, a 3-ethylmalate synthase (EC is an enzyme that catalyzes the chemical reaction

butanoyl-CoA + H2O + glyoxylate 3-ethylmalate + CoA

The 3 substrates of this enzyme are butanoyl-CoA, H2O, and glyoxylate, whereas its two products are 3-ethylmalate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming). Other names in common use include 2-ethyl-3-hydroxybutanedioate synthase, and 3-ethylmalate glyoxylate-lyase (CoA-butanoylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • RAMASARMA T, GIRI KV (1956). "Phosphoglucose isomerase of green gram (Phaseolus radiatus)". Arch. Biochem. Biophys. 62: 91&ndash, 6. PMID 13314642.

External links

The CAS registry number for this enzyme class is 9024-01-5.

Gene Ontology (GO) codes