3',5'-cyclic-GMP phosphodiesterase

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In enzymology, a 3',5'-cyclic-GMP phosphodiesterase (EC is an enzyme that catalyzes the chemical reaction

guanosine 3',5'-cyclic phosphate + H2O guanosine 5'-phosphate

Thus, the two substrates of this enzyme are guanosine 3',5'-cyclic phosphate and H2O, whereas its product is guanosine 5'-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is 3',5'-cyclic-GMP 5'-nucleotidohydrolase. Other names in common use include guanosine cyclic 3',5'-phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'-monophosphate phosphodiesterase, cyclic guanosine 3',5'-phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1MC0, 2CHM, 2H40, 2H42, and 2H44.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Marks F and Raab I (1974). "The second messenger system of mouse epidermis. IV. Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368&ndash, 377.

External links

The CAS registry number for this enzyme class is 9068-52-4.

Gene Ontology (GO) codes