21-hydroxylase deficiency secondary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [2]

Overview

Continued monitoring of hormone balance and careful readjustment of glucocorticoid dose is helpful in controlling fertility and preventing adrenal crisis in patient with 21-hydroxylase deficiency.

Secondary Prevention

Preventing hyperandrogenism and optimizing fertility

Continued monitoring of hormone balance and careful adjustment of glucocorticoid dose is helpful in controlling infertility. In general, women with 21-hydroxylase deficiency have a lower fertility rate.[1]

Preventing adrenal crisis

To prevent adrenal crisis, all patients taking glucocorticoids replacement should take bolus dose of glucocorticoids during severe illness, surgery and severe exhaustion.

References

  1. Mnif MF, Kamoun M, Kacem FH, Mnif F, Charfi N, Naceur BB, Rekik N, Abid M (2013). "Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency". Indian J Endocrinol Metab. 17 (5): 790–3. PMC 3784860Freely accessible. PMID 24083158. doi:10.4103/2230-8210.117196. 

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