1-pyrroline-5-carboxylate dehydrogenase

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In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O L-glutamate + NADH + H+

The 3 substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD+, and H2O, whereas its 3 products are L-glutamate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase. Other names in common use include Delta1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 2BHP, 2BHQ, 2BJA, 2BJK, 2EHQ, 2EHU, 2EII, 2EIT, 2EIW, 2EJ6, 2EJD, 2EJL, 2IY6, and 2J40.


External links

The CAS registry number for this enzyme class is 9054-82-4.

Gene Ontology (GO) codes