Jump to: navigation, search

In enzymology, a 1-phosphofructokinase (EC is an enzyme that catalyzes the chemical reaction

ATP + D-fructose 1-phosphate ADP + D-fructose 1,6-bisphosphate

Thus, the two substrates of this enzyme are ATP and D-fructose 1-phosphate, whereas its two products are ADP and D-fructose 1,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-fructose-phosphate 6-phosphotransferase. Other names in common use include fructose-1-phosphate kinase, 1-phosphofructokinase (phosphorylating), D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, and phosphofructokinase 1. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JG5.


External links

The CAS registry number for this enzyme class is 37278-03-8.

Gene Ontology (GO) codes