- ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase. Other names in common use include diphosphoinositide kinase, PIP kinase, phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of actin cytoskeleton.
- IUBMB entry for 184.108.40.206
- BRENDA references for 220.127.116.11 (Recommended.)
- PubMed references for 18.104.22.168
- PubMed Central references for 22.214.171.124
- Google Scholar references for 126.96.36.199
- Kai M, Salway JG, Hawthorne JN (1968). "The diphosphoinositide kinase of rat brain". Biochem. J. 106: 791–801. PMID 4295336.
- Kai M, Salway JG, Michell RH and Hawthorne JN (1966). "The biosynthesis of triphosphoinositide by rat brain in vitro". Biochem. Biophys. Res. Commun. 22: 370–375.
- Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390: 192–6. PMID 9367159.
- The CAS registry number for this enzyme class is 104645-76-3.