1-aminocyclopropane-1-carboxylate deaminase

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In enzymology, a 1-aminocyclopropane-1-carboxylate deaminase (EC is an enzyme that catalyzes the chemical reaction

1-aminocyclopropane-1-carboxylate + H2O 2-oxobutanoate + NH3

Thus, the two substrates of this enzyme are 1-aminocyclopropane-1-carboxylate and H2O, whereas its two products are 2-oxobutanoate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is 1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing). This enzyme is also called 1-aminocyclopropane-1-carboxylate endolyase (deaminating). This enzyme participates in propanoate metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1RQX, 1TYZ, 1TZ2, 1TZJ, 1TZK, and 1TZM.


External links

The CAS registry number for this enzyme class is 69553-48-6.

Gene Ontology (GO) codes