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In enzymology, a 1,6-alpha-L-fucosidase (EC is an enzyme that catalyzes the chemical reaction

Hydrolysis of 1,6-linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase. This enzyme is also called alpha-L-fucosidase.


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The CAS registry number for this enzyme class is 102925-35-9.