1,3-Dipolar cycloaddition

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The 1,3-dipolar cycloaddition, also known as the Huisgen cycloaddition or Huisgen reaction, [1] [2] is an organic chemical reaction belonging to the larger class of cycloadditions. It is the reaction between a 1,3-dipole and a dipolarophile, most of which are substituted alkenes, to form a five-membered ring. Rolf Huisgen first saw the prospects of varying the 1,3-dipole and its high value for synthesis of 5-membered heterocycles.

Classes of 1,3-dipoles

Huisgen and others investigated a range of 1,3-dipoles and dipolarophiles. These included:


ar:إضافة حلقية 3,1-ثنائية القطبية