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IUPAC name Propane-1,3-diol
Other names Trimethylene glycol
CAS number 504-63-2
Molecular formula C3H8O2
Molar mass 76.09 g/mol
Density 1.0597 g/cm³
Melting point

-28 °C

Boiling point

210-212 °C

Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

1,3-Propanediol, also propane-1,3-diol or trimethylene glycol, is a three-carbon diol. It is a clear colorless viscous liquid that is miscible with water and ethanol.[1]

1,3-Propanediol can be formulated into a variety of industrial products including composites, adhesives, laminates, coatings, moldings, novel aliphatic polyesters, copolyesters, solvents, antifreeze and other end uses.

1,3-Propanediol does not appear to pose a significant hazard via inhalation of either the vapor or a vapor/aerosol mixture.[2]

Currently 1,3-propanediol is being produced by Dupont Tate & Lyle Bioproducts, a joint venture between DuPont and Tate & Lyle, in Loudon, Tennessee. Dubbed Bio-PDO, it's being produced with genetically modified strain of E. coli that's fed a refined corn syrup. The bacteria, after a fermentation process, then produces Bio-PDO. Most in the industry refer to Bio-PDO as "Liquid Diamonds", due to the crystal clear liquid that is the final product.

See also


  1. Merck Index, 11th Edition, 9629.
  2. Scott RS, Frame SR, Ross PE, Loveless SE, Kennedy GL. (2005). "Inhalation toxicity of 1,3-propanediol in the rat". Inhal Toxicol. 17 (9): 487–93. PMID 16020043. doi:10.1080/08958370590964485. 

External links