(heparan sulfate)-glucosamine N-sulfotransferase

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In enzymology, a [heparan sulfate]-glucosamine N-sulfotransferase (EC 2.8.2.8) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and [[[heparan sulfate]-glucosamine]], whereas its two products are adenosine 3',5'-bisphosphate and [[[heparan sulfate]-N-sulfoglucosamine]].

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase. Other names in common use include heparin N-sulfotransferase, 3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase, PAPS:N-desulfoheparin sulfotransferase, PAPS:DSH sulfotransferase, N-HSST, N-heparan sulfate sulfotransferase, heparan sulfate N-deacetylase/N-sulfotransferase, heparan sulfate 2-N-sulfotransferase, heparan sulfate N-sulfotransferase, heparan sulfate sulfotransferase, N-desulfoheparin sulfotransferase, desulfoheparin sulfotransferase, 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase, heparitin sulfotransferase, and 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase.

References

  • IUBMB entry for 2.8.2.8
  • BRENDA references for 2.8.2.8 (Recommended.)
  • PubMed references for 2.8.2.8
  • PubMed Central references for 2.8.2.8
  • Google Scholar references for 2.8.2.8
  • Suzuki S, Trenn RH and Strominger JL (1961). "Separation of specific mucopolysaccharide sulfotransferases". Biochim. Biophys. Acta. 50: 169&ndash, 174.
  • Eisenman RA, Balasubramanian AS, Marx W (1967). "3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction". Arch. Biochem. Biophys. 119: 387&ndash, 97. PMID 4964017.
  • Johnson AH, Baker JR (1973). "The enzymatic sulphation of heparan sulphate by hen's uterus". Biochim. Biophys. Acta. 320: 341&ndash, 51. PMID 4270798.

External links

The CAS registry number for this enzyme class is 9026-75-9.

Gene Ontology (GO) codes


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