(heparan sulfate)-glucosamine 3-sulfotransferase 3

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In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 3 (EC is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and [[[heparan sulfate]-glucosamine]], whereas its two products are adenosine 3',5'-bisphosphate and [[[heparan sulfate]-glucosamine 3-sulfate]].

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase. This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.


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  • RD (1999). "Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues". J. Biol. Chem. 274: 38155&ndash, 62. PMID 10608887.
  • Eisenberg RJ, Rosenberg RD, Spear PG (1999). "A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry". Cell. 99: 13&ndash, 22. PMID 10520990.
  • Jenkins NA, Rosenberg RD (1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J. Biol. Chem. 274: 5170&ndash, 84. PMID 9988767.
  • Rosenberg RD (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities". J. Biol. Chem. 274: 5185&ndash, 92. PMID 9988768.

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