(deoxy)nucleoside-phosphate kinase

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In enzymology, a (deoxy)nucleoside-phosphate kinase (EC 2.7.4.13) is an enzyme that catalyzes the chemical reaction

ATP + deoxynucleoside phosphate ADP + deoxynucleoside diphosphate

Thus, the two substrates of this enzyme are ATP and deoxynucleoside phosphate, whereas its two products are ADP and deoxynucleoside diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:deoxynucleoside-phosphate phosphotransferase. Other names in common use include deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, and deoxynucleoside-5'-monophosphate kinase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1DEK and 1DEL.

References

  • IUBMB entry for 2.7.4.13
  • BRENDA references for 2.7.4.13 (Recommended.)
  • PubMed references for 2.7.4.13
  • PubMed Central references for 2.7.4.13
  • Google Scholar references for 2.7.4.13
  • BESSMAN MJ, HERRIOTT ST, ORR MJ (1965). "THE ENZYMOLOGY OF VIRUS-INFECTED BACTERIA. VI. PURIFICATION AND PROPERTIES OF THE DEOXYNUCLEOTIDE KINASE INDUCED BY BACTERIOPHAGE T5". J. Biol. Chem. 240: 439&ndash, 45. PMID 14253449.

External links

The CAS registry number for this enzyme class is 37278-20-9.

Gene Ontology (GO) codes


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