(acetyl-CoA carboxylase) kinase

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In enzymology, a [acetyl-CoA carboxylase] kinase (EC 2.7.11.27) is an enzyme that catalyzes the chemical reaction

ATP + [acetyl-CoA carboxylase] ADP + [acetyl-CoA carboxylase] phosphate

Thus, the two substrates of this enzyme are ATP and [[[acetyl-CoA carboxylase]]], whereas its two products are ADP and [[[acetyl-CoA carboxylase] phosphate]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[acetyl-CoA carboxylase] phosphotransferase. Other names in common use include acetyl coenzyme A carboxylase kinase (phosphorylating), acetyl-CoA carboxylase bound kinase, acetyl-CoA carboxylase kinase, acetyl-CoA carboxylase kinase (cAMP-independent), acetyl-CoA carboxylase kinase 2, acetyl-CoA carboxylase kinase-2, acetyl-CoA carboxylase kinase-3 (AMP-activated), acetyl-coenzyme A carboxylase kinase, ACK2, ACK3, AMPK, I-peptide kinase, and STK5.

References

  • IUBMB entry for 2.7.11.27
  • BRENDA references for 2.7.11.27 (Recommended.)
  • PubMed references for 2.7.11.27
  • PubMed Central references for 2.7.11.27
  • Google Scholar references for 2.7.11.27
  • Jamil H, Madsen NB (1987). "Phosphorylation state of acetyl-coenzyme A carboxylase. I. Linear inverse relationship to activity ratios at different citrate concentrations". J. Biol. Chem. 262: 630–7. PMID 2879833. 
  • Lent B, Kim KH (1982). "Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase". J. Biol. Chem. 257: 1897–901. PMID 6120170. 
  • Munday MR, Hardie DG (1984). "Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity". Eur. J. Biochem. 141: 617–27. PMID 6146523. 
  • Mohamed AH, Huang WY, Huang W, Venkatachalam KV, Wakil SJ (1994). "Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver". J. Biol. Chem. 269: 6859–65. PMID 7907095. 
  • Heesom KJ, Moule SK, Denton RM (1998). "Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase". FEBS. Lett. 422: 43–6. PMID 9475166. 

External links

The CAS registry number for this enzyme class is 77000-06-7.

Gene Ontology (GO) codes

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