- 4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (S)-norcoclaurine + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (S)-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in alkaloid biosynthesis i.
- IUBMB entry for 188.8.131.52
- BRENDA references for 184.108.40.206 (Recommended.)
- PubMed references for 220.127.116.11
- PubMed Central references for 18.104.22.168
- Google Scholar references for 22.214.171.124
- Stadler R, Zenk MH (1990). "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline". Liebigs Ann. Chem.: 555–562.
- Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis". Phytochemistry. 28: 1083–1086.
- Samanani N, Facchini PJ (2002). "Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277: 33878–83. PMID 12107162.
- The CAS registry number for this enzyme class is 79122-01-3.