(S)-methylmalonyl-CoA hydrolase

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In enzymology, a (S)-methylmalonyl-CoA hydrolase (EC is an enzyme that catalyzes the chemical reaction

(S)-methylmalonyl-CoA + H2O Failed to parse (MathML with SVG or PNG fallback (recommended for modern browsers and accessibility tools): Invalid response ("Math extension cannot connect to Restbase.") from server "https://api.formulasearchengine.com/v1/":): \rightleftharpoons methylmalonate + CoA

Thus, the two substrates of this enzyme are (S)-methylmalonyl-CoA and H2O, whereas its two products are methylmalonate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-methylmalonyl-CoA hydrolase. This enzyme is also called D-methylmalonyl-coenzyme A hydrolase. This enzyme participates in propanoate metabolism.


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The CAS registry number for this enzyme class is 87928-03-8.

Gene Ontology (GO) codes