(RS)-norcoclaurine 6-O-methyltransferase

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In enzymology, a (RS)-norcoclaurine 6-O-methyltransferase (EC is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (RS)-norcoclaurine S-adenosyl-L-homocysteine + (RS)-coclaurine

Thus, the two substrates of this enzyme are S-adenosyl methionine and (R,S)-norcoclaurine, whereas its two products are S-adenosylhomocysteine and (R,S)-coclaurine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.


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  • Rueffer M, Nagakura N, Zenk MH (1983). "Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransfera se from Argemone platyceras cell cultures". Planta Med. 49: 131&ndash, 137.
  • Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y (1994). "Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells". Eur. J. Biochem. 225: 125&ndash, 31. PMID 7925429.
  • Stadler R, Zenk MH (1990). "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline". Liebigs Ann. Chem.: 555&ndash, 562.

External links

The CAS registry number for this enzyme class is 167398-06-3.

Gene Ontology (GO) codes