Bubonic plague pathophysiology

Classification
Yersinia was        formerly classified in the family Pasteurellaceae, but based on         DNA- DNA hybridization similarities to Escherichia coli, the Yersinia         group has been reclassified as members of the Enterobacteriaceae         family (Farmer, 1995). Differentiation of the Enterobacteriaceae        family members is based on biochemical and antigenic profiles. More recently,        nucleic acid techniques have been applied to assist the definition of         genera and species within this family; hence, as more techniques are applied,         newly defined genetic relationships sometimes lead to changes in classification. Though there are 11 named species in the genus Yersinia, only 3        are considered important human pathogens: Y. pestis, the etiologic         agent of plague, and the enteropathogenic strains, Y. pseudotuberculosis         and Y. enterocolitica. Y. pseudotuberculosis is the closest         genetic relative to Y. pestis but can be distinguished from the         plague bacteria by its clinical manifestations and by laboratory test         results. Both Y. pestis and Y. pseudotuberculosis do not        frequently infect humans in contrast to Y. enterocolitica, which         may be more commonly found in clinical specimens.

Pathogenesis
A very small number of the Yersinia Pestis organisms are needed to infect a mammal. As little as 1 to 10 organisms would be enough to infect a small mammal, such as a rodent or primate, with the plague via subcutaneous, oral, intravenous, and intradermal routes. On the other hand, the respiratory route will take approximately 100 to 200,000 organisms for nonhuman primates. When the bacteria enters the host, there are a multitude of environmental signals that are believed to induce the synthesis and many other factors the contribute to the virulence of the bacteria. These environmental signals include things such as: During the incubation phase, the common symptom of bubonic plague, the bubo, is because the bacilli most commonly spreads to regional lymph nodes. The infection will rapidly progress if it is left untreated and then septicemia will develop and the infection will spread to other organs. Cyanosis and necrosis are commonly seen in septicemic plague, which may be caused by coagulase activity of the plasminogen activator. There are a few tissues that are most commonly infected. They include :
 * Elevated temperature
 * Location within cells at low pH
 * Contact with Eukaryotic cells
 * Liver
 * Lungs
 * Skin
 * Mucous membranes
 * Spleen
 * Also, late infection of meninges possible